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Neuroendocrine regulation of energy balance: Implications on the development and surgical treatment of obesity Gisele Farias, Brbara Dal Molin Netto, Solange Cravo Bettini, Ana Raimunda Dmaso, Alexandre Coutinho Teixeira de Freitas, Lipo Peptide Protocol Dosage Chart TikTok Ro has launched a new GLP 1 pill in partnership with Novo Nordisk., CEO Zach Reitano on how the pill will "usher in a new era of digital health":, "It's the first time a drug of this size and scale names of glp 1 medications GLP 1R agonists approved by the United States FDA and international GLP 1 Drugs and Eating Disorders: A Hidden Risk in the Weight Loss Revolution The Chicago Council on Science and Technology
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4.6 ★★★★★
Based on 6 reviews
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Product Reviews
★★★★★ 5
A Truly Ergonomic Mouse
Number of Items: 1
Other not completely flat mice claim to be "ergonomic", but the only way to completely remove stress from your forearm when using a mouse is with a "vertical" mouse. My 2020 K75575WW Kensington ergonomic vertical mouse developed a problem with the left button "stuttering" so that it sent multiple button clicks when pressed just once. I liked the Kensington quite a bit. But it always just a little bit on the "not quite as solid as I would like" side, and failing after just 2.5 years confirmed this. So I wanted a more solidly build mouse.
A search for "ergonomic mouse review" showed that the Logitech MX Master 3S was clearly the best ergonomic mouse available. At $100 it was several times more expensive as others including the latest Kensington vertical mouse. But sometimes furgal doesn't mean the least expensive. Sometimes it can mean the most expensive if that comes with better performance, features and lifespan. So I ordered it. And while it is indeed an incredible mouse, the angle is only about 20 degrees. The result is that while there is some reduction in forearm stress compared to a flat mouse, it wasn't enough for me. By the end of my very long days driving my mouse almost as much as I drive my keyboard, I could feel the tension building up in my forearm. So after a week I returned it and bought this Logitech MX Vertical.
It is slightly less expensive than the MX Master 3S, but still much more expensive relative to other options. And while it is lighter and a little less substantial feeling in my hand than the MX Master 3S, it still feels very firm and solid. Most importantly keeps my hand in the neutral position with my fingers at about 70 degrees. A great feature of the MX Vertical shares with the MX Master 3S is the thumb rest. The Kensington didn't have this and so my thumb rested on the desktop. If it was a bit warm and my hands would sweat my thumb wouldn't slide smoothly and I would have to lift my thumb off the desk when I went to move the mouse. Not a horrible thing, but if you spend 8+ hours mousing around it gets tiresome. The button clicks are crisp. Best of all when the button bottoms out it feels like it is pressing against the case. It doesn't feel like travel is being limited by the switch itself bottoming out like the Kensington felt like it did. My hope is that this will keep the switch from wearing out so fast as happened with the Kensington.
One slight negative of the MX Vertical is that I don't feel like I am quite as accurate in being able to move the cursor to a specific spot on the screen without some amount of conscious effort. Instead it doesn't go exactly in the direction I intended and overshoots where wanted it to stop. As such it might not make the best mouse for video games. [UPDATE: There is a bit of a learning curve in moving the mouse accurately. In the last couple weeks my need to make a more conscious effort to move the mouse to a specific spot on the screen is going down. Still think it is likely to not be as accurate as a flater mouse]
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Reviewed in the United States on February 13, 2023
★★★★★ 5
Ergonomic, Comfortable, and Highly Functional Mouse
Number of Items: 1
The Logitech MX Vertical Wireless Mouse is an outstanding ergonomic mouse that truly reduces wrist and forearm strain. Its vertical design feels natural and comfortable, even during long hours of use, making it a great choice for anyone concerned about repetitive strain or discomfort.
The mouse connects seamlessly via Bluetooth or the included USB receiver, and the ability to switch between three different devices is incredibly convenient for multitasking. The precision and smooth tracking make it excellent for both work and creative tasks.
Overall, this mouse combines comfort, functionality, and versatility in one sleek package. It’s well worth the investment for anyone looking to improve ergonomics and productivity.
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Reviewed in the United States on December 29, 2025
★★★★★ 5
Great mouse
Number of Items: 1
Definitely reduces fatigue. Easy to use. Great response with less space needed for mouse movement. Stays charged for months you actually forget to charge it, ask me how I know :). I play video games with it and never have any issues with the movement and response time of mouse. And since my car wreck where I broke my thumb this is the only mouse that gave me the same as before the wreck abilities to move and operate the mouse. Highly recommend. One very broken thumbs up :)
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Reviewed in the United States on May 31, 2026
★★★★★ 4
Experience after one year of usage
Number of Items: 1
I had mainly used a MX Master 2S before this and because of my heavy usage I did start to feel uncomfortable after a few hours of use every day and that's when I decided to purchase MX Vertical. Now after almost 9 months of usage this has become the mouse I use on a daily basis, completely replacing MX Master 2S.
Comfort: It took me about a day or two to really get used to using it because of the positioning and ever since then my wrist has never felt any discomfort, literally. I don't have a mouse pad but because of the angle that my wrist is contact with the desk when I use it, this has never been a problem. What I also love about the ergonomic design is that my hand can actually just rest on it when not doing specific tasks, and it just fits my palm perfectly.
Functionality: I don't use it for gaming so I can't comment on that. However, comparing it with my Master 2S, there are some very obvious disadvantages. If you use Excel sheets a lot, or anything that requires horizontal viewing, the scrolling option is terrible. You can set up the function key on Logi Options+ and I use the side buttons for scroll right+left mainly because how easy it was to use with the Master 2S's side scrolling buttons. It is not comparable at all. With Master 2s, horizontal scrolling is smooth and precise. With this, it's basically useless. There are sites that just aren't responsive to the side buttons and when they do, you can never get to the precise point you want. Huge disappointment with that because I don't really use the side buttons for anything else. There is also no scrolling control with the middle button unlike the Master 2S, so you can't really scroll vertically as fast as you can when using Master 2S either. However I do use the middle button sometimes to just do the job for me so I'm ok with its basic functionality.
The top button is mainly used as a look-up button for me, so far its working pretty well and honestly it probably makes not much difference if they just completely take this button out for me. Maybe some people can find use in it as a switch for scrolling or mouse speed, or something else. Overall, the customizability of these buttons is very good, and depending on personal use, I can see it being very useful.
Battery life: Battery life is fantastic, never had any problem with it yet. I haven't really kept track but with my heavy daily usage (probably 10+ hours with no intense gaming), it can usually go for more than a month. You can also use it while it's being charged.
Durability: I have unfortunately knocked it over the desk a couple times on hard vinyl floor and there seems to be no problem with it at all. Before purchasing this I saw some comments about how it stopped functioning after being dropped to the floor and I was really worried about it. However that is not my case at all. It is very durable in my opinion and does its job perfectly even after dropping it a few times.
Overall, extremely comfortable to use. It helped with my wrist pain tremendously and now I use it for hours without feeling any discomfort. The functionality is severely disadvantageous compared to Master 2s and 3s, and possibly other gaming mouses as well, but if you are here because of wrist pain, this is the right product.
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Reviewed in the United States on May 24, 2024
★★★★★ 5
Finally, a comfortable vertical mouse for guys with large hands!
Number of Items: 1
I've been using the Logitech MX Vertical Wireless Mouse for about 8 years now, and I love it. Any time I have to use a traditional mouse it's an uncomfortable disappointment.
If you haven't used a vertical mouse yet, there are a couple things you need to know.
First - this is just a normal mouse, but it's turned about 60-degrees to the right. This let's your hand rest on the mouse in the natural position your arm wants it to be in without any effort to rotate.
Second - you will knock it over, repeatedly, for a few weeks. Because you're used to a mouse that's a just an inch and a half or so tall, your natural movement from keyboard to mouse is going to be interrupted by the height of the MX Vertical. In time, you will get used to this, but for a week or two, you will knock it over when moving to the mouse, and when moving back to the keyboard. Don't worry, your muscle memory will change and this will stop.
Third - once you get used to using the MX Vertical, you won't want to use any other mouse. It's a dramatic change in ergonomics, and you will feel the strain your wrist and forearm are under any time you have to use a traditional mouse.
There are other verticals that are also great, but as a guy with large hands, this is the best I've found. I have 4 of these now - one at my office, one at my dining room table, one at my desk, and one that travels in my backpack. I don't need all of these, but its handy having them where I need them. Another reason for this is the mouse can pair with 3 devices. I have different devices in each of these locations, so it's handy not having to re-pair when I move between locations.
The MX Vertical fits my hand perfect, and all buttons are where my fingers and thumb are naturally positioned. I've dropped them, knocked them down, bumped and tossed them and they keep on working properly, so from a durability standpoint, this will last. It's easy to pair with a push of a button - working with my Windows computers, MacBook, android phone and iPad. This thing just works great!
The only downside I'd mention is the coating. After a couple of years, the coating tends to migrate where you apply pressure. This is most apparent where the thumb and pinky finger rest. This doesn't cause any functional issues, and is entirely cosmetic, but just be aware that after a couple years it won't look pristine.
All-in-all, this is the vertical mouse to buy if you're a guy with larger hands. Get one, get used to it, and you won't regret it.
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Reviewed in the United States on February 6, 2026
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