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Description
Patients with obesity, type 2 #diabetes and chronic kidney disease are at high risk for kidney failure, cardiovascular events, and death. This study, the FLOW trial now published, evaluated treatment with semaglutide (# Does Semaglutide Need To Be Refrigerated? SugarMD Injectable GLP 1 drugs have transformed obesity treatment and now they're going oral. The FDA recently approved a pill form of semaglutide (Wegovy) for weight loss and for reducing the risk of Semaglutide drives weight loss through cAMP dependent mechanisms in GLP1R expressing hindbrain neurons Nature Metabolism Semaglutide Microdose GoodGirlRx
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4.9 ★★★★★
Based on 27 reviews
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Product Reviews
★★★★★ 4
Good, but you sacrifice a few things in favor of style
Color: Black Leather/Black, Size: 10, Color: Black Leather/Black, Size: 10
It’s much better than other shoes out there, but the design is slightly confusing. The first thing you have to know is that the shoe won’t be mind blowingly soft, but it is around as comfortable as standing on something like vans shoes. The holes on top are both a plus and a minus, when you step in a puddle, your feet get instantly soaked, but just by walking around for a bit, they dry up again. Then these holes reduce the structural integrity of the shoe, so I expect the top to be the first part of the shoe that deteriorates, when usually for all my other shoes, it’s the sole that falls off first. With the holes, you can’t shine them the traditional way, you have to be more careful as you might get goo into the inside fiber. Finally you can’t run in these, they’re larger than your foot which is quite comfortable while just standing or walking, but I’m sure they’ll tear if you don’t watch your footing. If all that is okay with you, You’ll get quite a few compliments on it as you walk around, because these are beautiful and excellent as a dress shoe/loafer hybrid
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Reviewed in the United States on September 11, 2025
★★★★★ 5
Great gift for any guy!
Color: Black Leather/Black, Size: 12
These are one of 2 pairs of work shoes my husband will wear, the other one is the same shoe in brown. He says they’re the comfiest pair of dress shoes he’s ever had and the quality and ease of cleaning is incredible. They’ve lasted him years now so I’d say they’re well worth the money.
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Reviewed in the United States on April 7, 2026
★★★★★ 5
Fit like a glove
Color: Black Leather/Black, Size: 12
I saw somebody wearing these a couple years ago, and I've been looking for him for a while. I really like them.They're very comfortable
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Reviewed in the United States on April 30, 2026
★★★★★ 5
Stylish and comfortable
Color: Black Leather/Black, Size: 13 Wide
Very few dress shoes fit me comfortably on the first try. I have been on my feet for 6 hours and these shoes are very comfortable and provide great support! Very happy with this pair of Cole Haan shoes!!
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Reviewed in the United States on January 8, 2026
★★★★★ 5
Great shoes
Size: 10 Wide, Color: Brown, Size: 10 Wide, Color: Brown
This shoe is incredibly comfortable and durable.
I work in custodial work as management. However, sometimes I have to help my team when we are low manned. Just recently I had to help my team auto scrub a restroom. My shoes felt lightweight and were completely easy to clean. I was worried I would be slipping on sudsy water. To my surprise, these shoes gripped on to the floor nicely.
I love the versatility of having a working shoe with the great style Bruno Marc provides. The shoe is breathable and true to size. I ordered the black pair as well and have had them for about 3 months. Highly recommend these amazing shoes.
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Reviewed in the United States on May 28, 2026
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